CAS 40596-69-8 | Methoprene

Introduction
Methoprene acts as a tobacco leaf protectant and interferes with the insect peeling process. It can interfere with the growth and development process of tobacco beetles and tobacco powder borers, and make adults lose their reproductive ability, thereby effectively controlling the growth of stored tobacco pests.

Specification of CAS 40596-69-8 | METHOPRENE

Synthesis of CAS 40596-69-8 | METHOPRENE

Conditions

Multi-step reaction with 7 steps 

1: Et3N / N-(2-hydroxyethyl)-thiazolium bromide / dioxane / 20 h / 95 - 100 °C 

2: sodium borohydride / tetrahydrofuran / 1 h / 0 °C 

3: pyridine / 24 h / 25 °C 

4: potassium t-butoxid, 18-Crown-6 / benzene / 0.5 h / Ambient temperature 

5: sodium borohydride / propan-2-ol / 4 h / Heating 

6: PBr3, LiBr, 2,4,6-collidine / 3 h / -40 - 0 °C 

7: 1.) ZnBr, 2.) DBU / 1.) ether, -40 deg C to 0 deg C, 2 h, 2.) 50 deg C, 2 h

Reference

Baan, Gabor; Vinczer, Peter; Novak, Lajos; Szantay, Csaba 

[Tetrahedron Letters, 1985, vol. 26, # 35, p. 4261 - 4264]

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