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CAS 27143-07-3 | Acetic Acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], Ethyl Ester
Molecular Formula: C11H13ClN2O3
Molecular Weight: 256.69
EINECS: 608-053-7
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg
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Product Introduction
Introduction
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester is an ester derivative, which is an intermediate in the synthesis of apixaban.
Specification of CAS 27143-07-3 | Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester
ITEMS | SPECIFICATION |
pka | 11.63 |
Melting point | 94℃ |
density | 1.23 |
storage temp. | Sealed in dry,2-8°C |
Boiling point | 349.0 °C |
Synthesis of CAS 27143-07-3 | Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester
Conditions
Stage #1: 4-methoxy-aniline With hydrogenchloride; sodium nitrite In ethanol; water at 0 - 5℃; for 0.5h; Stage #2: ethyl 2-chloro-3-oxo-butyrate With sodium acetate In ethanol; water at 0 - 25℃;
Reference
Liu, Ju; Nie, Minhua; Wang, Yanjing; Hu, Jinxing; Zhang, Feng; Gao, Yanlin; Liu, Yajing; Gong, Ping [European Journal of Medicinal Chemistry, 2016, vol. 123, p. 431 - 446]
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