CAS 545445-44-1 | 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Molecular Formula: C20H25N3O3
Molecular Weight: 355.43
EINECS: 1308068-626-2
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg
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Product Introduction
Introduction
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one is an intermediate for the preparation of apixaban.
Specification of CAS 545445-44-1 | 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
ITEMS | SPECIFICATION |
Boiling point | 625.0 °C |
pka | 3.25 |
storage temp. | Sealed in dry,2-8°C |
density | 1.267 |
Synthesis of CAS 545445-44-1 | 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Conditions
Stage #1: 5-Chlorovaleroyl chloride; 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one With tetrabutylammomium bromide; sodium hydroxide In dichloromethane; water at 0 - 5℃; for 1h;
Stage #2: With potassium hydroxide In dichloromethane; water at 20℃; Reagent/catalyst; Solvent; Temperature;
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