CAS 4684-94-0 | 6-Chloropicolinic Acid
Molecular Formula: C6H4ClNO2
Molecular Weight: 157.55
EINECS: 628-517-2
Purity: 97% Min.
Package: 100 g / 1 kg / 25 kg
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Product Introduction
Introduction
6-Chloropyridine-2-carboxylic acid is an intermediate of Sorafenib b.
Specification of CAS 4684-94-0 | 6-Chloropicolinic acid
ITEMS | SPECIFICATION |
Melting point | 190-191°C |
InChIKey | ZLKMOIHCHCMSFW-UHFFFAOYSA-N |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
color | White to cream to tan |
refractive index | 1.5870 |
form | Crystalline Powder |
λmax | 294nm(EtOH)(lit.) |
Water Solubility | 3.40g/L(temperature not stated) |
density | 1.3768 |
Boiling point | 241.15°C |
pka | 3.27 |
EPA Substance Registry System | 6-Chloropicolinic acid (4684-94-0) |
BRN | 115849 |
CAS DataBase Reference | 4684-94-0(CAS DataBase Reference) |
Synthesis of CAS 4684-94-0 | 6-Chloropicolinic acid
Conditions
Stage #1: carbon dioxide With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate In 1,4-dioxane at 65℃; for 0.333333h; Schlenk technique;
Stage #2: 2,6-dichloropyridine With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 100℃; for 10h; Schlenk technique; Sealed tube;
Reference
Paridala, Kumaraswamy; Lu, Sheng-Mei; Wang, Meng-Meng; Li, Can
[Chemical Communications, 2018, vol. 54, # 82, p. 11574 - 11577]
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