CAS:111969-64-3 | L-Menthyl 2,2-Dihydroxyacetate

Name:L-Menthyl 2,2-Dihydroxyacetate

Synonyms:2,2-Dihydroxyacetic Acid (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl Ester; Dihydroxyacetic Acid (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl Ester; [1R-(1α,2β,5α)]-Dihydroxyacetic Acid 5-Methyl-2-(1-methylethyl)cyclohexyl Ester; 2,2-Dihydroxyacetic Acid (-)-Menthyl Ester

CAS:111969-64-3

Purity:98%

Molecular Formula:C₁₂H₂₂O₄

Molecular Weight:230.30

Melting Point:76-80°

Boiling Point:95-96°/0.3mm

Density:1.182g/cm³

Appearance:White to Off-White Solid

Sensitivity:Air Sensitive

Solubility:Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)

pKa:10.79±0.41(Predicted)

InChl:InChI=1S/C12H22O4/c1-7(2)9-5-4-8(3)6-10(9)16-12(15)11(13)14/h7-11,13-14H,4-6H2,1-3H3/t8-,9+,10-/m1/s1

InChl Key:BWZMJRSMHQDFIT-KXUCPTDWSA-N

Storage condition:Refrigerator, under inert atmosphere

Application:L-Menthyl 2,2-Dihydroxyacetate(CAS:111969-64-3) is used as a reagent in the synthesis of Lamivudine (L172500); a potent nucleoside reverse transcriptase inhibitor used for the treatment of chronic hepatitis B. L-Menthyl 2,2-Dihydroxyacetate is also used as a reagent in the synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one, a key intermediate for the preparation of penem and carbapenem antibiotics.

Reference: 

Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944); Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997); Perry, C.M., et al.: Drugs, 53, 657 (1977); Goodyear, M.D., et al.: Tetrahedron Lett., 46, 8535 (2005); Kametani, T., et al.: Heterocycles, 25, 241 (1987)

Packaging & Delivery

Package:5g/10g/25g/50g/bulk package

Transportation: by FeDex or by ocean shipping or clients requirement

Delivery Detail: Within 3-5 days after full payment

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