Home / Products / Life Science / Pharmaceutical Intermediates / Content

Products

CAS: 4291-63-8 Cladribine

CAS No.: 4291-63-8
Formula: C10H12ClN5O3
Molecular Weight: 285.68700
Purity: 97% Min.
Package: 5 g / 25 g / 100 g
Lead time: In stock
Delivery: DHL/FEDEX/UPS or By sea
Email: sale4@alfachemical.cn
Tel&whatsapp&Wechat: +16613886526

Worldwide Delivery
Quality Assurance
24/7 Customer Service

Product Introduction

Introduction
It is a substituted purine nucleoside with antileukemic activity. Cladribine is an adenosine deaminase inhibitor used to treat hairy cell leukemia and multiple sclerosis. Target: Adenosine DeaminaseCladribine possesses concentration-dependent apoptosis-inducing potential in the HSB2 cells. Cladribine inhibits growth of primary mast cell (MC) and the MC line HMC-1 in a dose-dependent manner, with lower IC50 values recorded in HMC-1.2 cells harboring KIT D816V compared to HMC-1.1 cells lacking KIT D816V. Cladribine (0.7-3.5 mM) and/or diltiazem (2.4 mM), is injected intraperitoneally into adult zebrafish and red blood cell (RBC) lysates are assayed by HPLC for levels of purine nucleotides (e.g. ATP), potential biomarkers of cardiovascular health. Diltiazem increased RBC ATP concentrations, which are inhibited by co-injection of cladribine.

Specification of CAS: 4291-63-8 Cladribine

ITEMS	SPECIFICATION
Melting point	181-185 °C(lit.)
InChIKey	PTOAARAWEBMLNO-HSUXUTPPSA-N
alpha	D25 -18.8° (c = 1 in DMF)
solubility	Slightly soluble in water, soluble in dimethyl sulfoxide, slightly soluble in methanol, practically insoluble in acetonitrile. It shows polymorphism (5.9).
Merck	14,2337
form	White solid
λmax	265nm(EtOH aq.)(lit.)
density	2.03±0.1 g/cm3
Stability	Store in Freezer
Boiling point	547.6±60.0 °C
pka	13.75±0.60
CAS DataBase Reference	4291-63-8(CAS DataBase Reference)
storage temp.	-20°C