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CAS:120068-37-3 | 5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile
Name:5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile
CAS:120068-37-3
Purity:98%
Molecular Formula:C12H4Cl2F6N4OS
Molecular Weight:437.15
Melting Point:203.92° C (Predicted)
Boiling Point:510.1° C at 760 mmHg (Predicted)
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Product Introduction
Name:5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile
Synonyms:Fipronil;Termidor
CAS:120068-37-3
Purity:98%
Molecular Formula:C12H4Cl2F6N4OS
Molecular Weight:437.15
Melting Point:203.92° C (Predicted)
Boiling Point:510.1° C at 760 mmHg (Predicted)
EINECS:424-610-5
Density:1.477-1.626g/cm3
Appearance:Off white powder
Solubility:DMF: 20 mg/ml;DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml;DMSO: 14 mg/ml;Ethanol: 10 mg/ml
Water solubility:1.9-2.4 mg 1l-1 (20 °C)
pKa:-5.86±0.20(Predicted)
Λmax:208nm(H2O)(lit.)
IC50 :GABA receptor alpha-4 subunit: IC50 = 2.3 nM (human); GABA receptor beta-3 subunit: IC50 = 28 nM (human)
refractive index:n20D 1.62 (Predicted)
Storage condition:Store at room temperature
InChi:InChI=1S/C12H4Cl2F6N4OS/c13-5-1-4(11(15,16)17)2-6(14)8(5)24-10(22)9(7(3-21)23-24)26(25)12(18,19)20/h1-2H,22H2
InChi Key:ZOCSXAVNDGMNBV-UHFFFAOYSA-N
Application:Fipronil(CAS:120068-37-3) is a channel blocker that blocks GABA-gated chloride channels and glutamate-activated chloride channels (GluCls). In Xenopus oocyte studies fipronil blocked the response of GABA receptors. Research shows that fipronil can increase levels of apoptosis in PC-12 cells. The binding of 4-n-[3H]propyl-4'-ethynylbicycloorthobenzoate ([3H]EBOB) to the GABA-gated chloride ion channel is inhibited by fipronil in Drosophila melanogaster.
Reference:
1. Hosie, A.M., et al. 1995. Br. J. Pharmacol. 115: 909-912. PMID: 7582519
2. Cole, L.M., et al. 1995. Life Sci. 56: 757-765. PMID: 7885191
3. Narahashi, T., et al. 2010. Pestic Biochem Physiol. 97: 149-152. PMID: 20563240
4. Hu, X.F., et al. 2010. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 28: 264-267. PMID: 20465951
Packaging & Delivery
Package:500g/1kg/5kg/10kg/bulk package
Transportation: by FeDex or by ocean shipping or clients requirement
Delivery Detail: Within 3-5 days after full payment
Flexible payment terms: support T/T, Paypal , Credit Card
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