CAS 877399-52-5 | Crizotinib
Molecular Formula: C21H22Cl2FN5O
Molecular Weight: 450.34
EINECS: 638-814-9
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg / 25 kg
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Product Introduction
Introduction
Crizotinib es un inhibidor de la tirosina quinasa (TKI) de molécula pequeña que se dirige a la quinasa del linfoma anaplásico (ALK), ROS1, y a otro receptor de tirosina quinasa oncogén, MET.
Specification of CAS 877399-52-5 | Crizotinib
ITEMS | SPECIFICATION |
Melting point | 192 °C |
Storage temp. | Room temp |
Color | White to tan |
Form | powder |
Density | 1.47 g/cm3 |
Boiling point | 599.2 °C |
pka | 9.81 |
CAS DataBase Reference | 877399-52-5 |
Synthesis of CAS 877399-52-5 | Crizotinib
Conditions
With hydrogenchloride In 1,4-dioxane; dichloromethane; water at 0 - 20℃; for 4h; Inert atmosphere;
Reference
Cui, J. Jean; Tran-Dubé, Michelle; Shen, Hong; Nambu, Mitchell; Kung, Pei-Pei; Pairish, Mason; Jia, Lei; (…) Kania, Robert S.; Edwards, Martin P.
[Journal of Medicinal Chemistry, 2011, vol. 54, # 18, p. 6342 - 6363]
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