CAS 775304-57-9 | Ataluren (PTC124)

Introduction
Ataluren (PTC124) selectively induces ribosome transcriptional read-through, but does not affect normal stop codons. EC5Chemicalbook0 is 0.1 μM in HEK293 cells, which can treat familial hereditary diseases caused by nonsensemutations (such as CF caused by nonsense mutations in CFTR)

Specification of CAS 775304-57-9 | Ataluren (PTC124)

Synthesis of CAS 775304-57-9 | Ataluren (PTC124)

Conditions

With basic cobalt(II) carbonate; sodium bromide In acetic acid at 95℃; for 11h; Green chemistry;

Reference

Krasouskaya; Danilova; Baikov; Kolobov; Kofanov

[Russian Chemical Bulletin, 2015, vol. 64, # 1, p. 142 - 145]

[Izv. Akad. Nauk, Ser. Khim., 2015, # 1, p. 142 - 145,4]

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