CAS 68181-17-9 | SPDP
Molecular Formula: C12H12N2O4S2
Molecular Weight: 312.36
EINECS: 269-034-3
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg
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Product Introduction
Introduction
SPDP (SPDP Crosslinker) is a short chain crosslinker that forms cleavable (reducible) disulfide bonds with cysteine sulfhydryls via NHS-ester and pyridyldithiol reactive groups , to realize the combination of amine and sulfhydryl. SPDP (SPDP Crosslinker) is a cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).
Specification of CAS 68181-17-9 | SPDP
ITEMS | SPECIFICATION |
Melting point | 84-86 °C(lit.) |
InChIKey | JWDFQMWEFLOOED-UHFFFAOYSA-N |
Storage temp. | -20°C |
Solubility | acetone |
Form | powder |
Density | 1.48 g/cm3 |
Boiling point | 465.9 °C |
pka | 1.76 |
BRN | 1548137 |
CAS DataBase Reference | 68181-17-9(CAS DataBase Reference) |
Synthesis of CAS 68181-17-9 | SPDP
Conditions
With dicyclohexyl-carbodiimide in dichloromethane at 0℃; for 2h;
Reference
Horikawa, Ryo; Sunayama, Hirobumi; Kitayama, Yukiya; Takano, Eri; Takeuchi, Toshifumi
[Angewandte Chemie - International Edition, 2016, vol. 55, # 42, p. 13023 - 13027]
[Angew. Chem., 2016, vol. 128, p. 13217 - 13221]
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