CAS:2444-46-4 | N-Vanillylnonanamide

Name:N-Vanillylnonanamide

Synonyms:N-Nonylvanylamide;N-Pelargonic Acid Vanillylamide;N-Pelargonylvanillylamide;Capsaicin (Synthetic)

CAS:2444-46-4

Purity:98%

Molecular Formula:C₁₇H₂₇NO₃

Molecular Weight:293.4

Melting Point:57° C

Boiling Point:492.7° C at 760 mmHg (Predicted)

Flash Point:190°C

Density:1.1 g/cm³

Appearance:white to pale brown crystalline powder

Stability:Stable. Incompatible with strong oxidizing agents

Solubility:methanol: 100 mg/mL, clear to slightly hazy

pKa:9.76±0.20(Predicted)

refractive index:1.45200

IC50 :Vanilloid receptor: EC5050 = 223 nM (rat); guinea pig: EC5050 = 400 nM; rat: EC5050 = 550 nM

Storage condition:refrigerate in tightly sealed containers

InChIKey:RGOVYLWUIBMPGK-UHFFFAOYSA-N

Application:N-Vanillylnonanamide(CAS:2444-46-4) is a naturally occuring analog of Capsaicin (sc-3577) isolated from peppers, described to produce effects similar to Capsaicin as an agonist of the VR1 (TRPV1 receptor. Nonivamide is demonstrated to stimulate afferent neurons with about half the potency of Capsaicin. Agonism of the VR1 (TRPV1) receptor by Nonivamide was demonstrated to induce the release of Ca2+ from the endoplasmic reticulum (ER) of human lung cells, producing ER stress and cell death.

Reference: 

1. Skofitsch, G., et al. 1984. Arzneimittelforschung. 34: 154-156. PMID: 6202305

2. Hayes, A.G., et al. 1984. Life Sci. 34: 1241-1248. PMID: 6708727

3. Suzuki, T., et al. 1998. J. Vet. Med. Sci. 60: 691-697. PMID: 9673939

4. Stücker, M., et al. 1999. Skin Pharmacol. Appl. Skin Physiol. 12: 289-298. PMID: 10461099

5. Reilly, C.A., et al. 2001. J. Forensic Sci. 46: 502-509. PMID: 11372985

6. Thomas, K.C., et al. 2007. J. Pharmacol. Exp. Ther. 321: 830-838. PMID: 17332266

Packaging & Delivery

Package:5g/10g/25g/50g/bulk package

Transportation: by FeDex or by ocean shipping or clients requirement

Delivery Detail: Within 3-5 days after full payment

Flexible payment terms: support T/T, Paypal , Credit Card

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