1286770-55-5 | Verubecestat (MK-8931)
Molecular Formula: C17H17F2N5O3S
Molecular Weight: 409.41
Solubility: DMSO (Slightly), Methanol (Slightly)
Purity: 97% Min.
Package: 5 mg / 10 mg / 25 mg
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Product Introduction
Introduction
Verubecestat (MK-8931) is a potent and selective beta-secretase (BACE) inhibitor.
Specification of CAS: 1286770-55-5 MK-8931
ITEMS | SPECIFICATION |
pka | 9.92 |
Storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
Density | 1.52±0.1 g/cm3 |
In vitro study:
Verubecestat (MK-8931) effectively reduces Aβ40 in cells with a Ki value of 7.8 nM and an IC50 of 13 nM.
In vivo study:
A single oral administration of Verubecestat (MK-8931) to rats and cynomolgus monkeys can significantly reduce cerebrospinal fluid (CSF) and cortical Aβ40. The half-life of MK-8931 in the body is 20 hours, which is suitable for the frequency of administration once a day.
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