1267610-26-3 | 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
Molecular Formula: C15H19N3O2
Molecular Weight: 273.33
Solubility: Chloroform (Slightly), Methanol (Slightly)
Purity: 97% Min.
Package: 5 g / 10 g / 100 g / 500 g
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Product Introduction
Introduction
It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
Specification of CAS: 1267610-26-3 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
ITEMS | SPECIFICATION |
Boiling point | Around 491.5 °C |
pka | 4.96±0.10 |
Storage temp. | Keep in dark place, Inert atmosphere,2-8°C |
Density | 1.277±0.06 g/cm3 |
Synthesis of CAS: 1267610-26-3
Hydrazine hydrate 80% (60 gm, 1.19 mol) was added drop wise at around 60-65° C. to the solution containing product of example-III (50 gm, 0.16 mol), Raney nickel (1 gm, 2%) in EtOH (750 ml) and water (150 ml). After completion of addition, stirred for 30 min at same temperature and brought to room temperature. The reaction mass was filtered through celite bed, concentrated under vacuum, added EtOAc (100 ml) and filter under suction. Dried the wet cake in air oven to afford the desired product as a cream colored solid. Yield: 43 gm; 95.55%
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