CAS:38183-03-8 | 7,8-Dihydroxyflavone

Name:7,8-Dihydroxyflavone

Synonyms:7,8-DHF; 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one

CAS:38183-03-8

Purity:98%

MDL No:MFCD00006836

Molecular Formula:C₁₅H₁₀O₄

Molecular Weight:254.24

Melting Point:250-252° C

Boiling Point:494.4° C at 760 mmHg

Density:1.4 g/cm³

Appearance:Pale yellow to greenish yellow solid

Solubility:DMF: 20 mg/ml;DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml;DMSO: 10 mg/ml;Ethanol: 1 mg/ml

Λmax:210, 270 nm

pKa:6.86±0.40(Predicted)

refractive index:n20D 1.70 (Predicted)

Storage condition:Inert atmosphere,Room Temperature

InChi:InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H

InChi Key:COCYGNDCWFKTMF-UHFFFAOYSA-N

Application:7,8-Dihydroxyflavone(CAS:38183-03-8) is disubstituted flavone that acts as a small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to reverse memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. 7,8-Dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as Rett syndrome and PTSD. It has recently been shown to counteract the inhibition of NMDA receptor caused by lead poisoning and confer protective effects in live rats.

Reference: 

Devi, L. et al.: Neuropsychopharmacology, 37, 434 (2012); Andero, R. et al.: Hippocampus, 22, 399 (2012); Johnson, R.A. et al.: J. Appl. Physiol., 112, 704 (2012); Chem. and Eng. News Nov. 20, 2017, page 5

Packaging & Delivery

Package:5g/10g/25g/50g/bulk package

Transportation: by FeDex or by ocean shipping or clients requirement

Delivery Detail: Within 3-5 days after full payment

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