1597403-47-8 ISRIB (trans-isoMer)
Molecular Formula: C12H25LiO4S
Molecular Weight: 272.33
EINECS: 218-058-2
Purity: 97% Min.
Package: 5 g / 25 g / 100 g
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Product Introduction
Introduction
Related categories: inhibitors; Small molecule inhibitors, natural products; Drug intermediates; API; Inhibitors; research chem
ISRIB is a potent and selective PERK inhibitor.
Specification of CAS: 1597403-47-8 ISRIB (trans-isoMer)
ITEMS | SPECIFICATION |
Boiling point | 719.0 °C |
pka | 13.63 |
storage temp. | 2-8°C |
density | 1.33 g/cm3 |
USE
A highly selective PERK inhibitor with IC50:5nM. trans-ISRIB is an Integrated Stress Response Inhibitor .trans-ISRIB inhibits the eIF2α phosphorylation-mediated unfolded protein response Chemicalbook following induction of ERstress (IC50=5nMinacell-reporterassay). ISRIB reverses the effects of eIF2α phosphorylation on and stress granule assembly.
Related articles
MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation
S Arai, A Varkaris, M Nouri, S Chen, L Xie, SP Balk - Elife, 2020 - elifesciences.org
Catalog Number: T6183 CAS Number: 1597403-47-8 Molecular Formula: C22H24Cl2N2O4 Molecular Weight: 451.34
I vitro Activity, I vivo Activity - targetmol.com
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