Current Situation Of Chemical Pharmaceutical Intermediates

At present, my country needs more than 2,000 kinds of raw materials and intermediates for chemical industry every year, and the demand is over 2.5 million tons. After more than 30 years of development, the chemical raw materials and intermediates required for my country's pharmaceutical production can basically be matched, and only a small part of it needs to be imported. Moreover, due to my country's abundant resources and low raw material prices, many intermediates have been exported in large quantities. So, what development opportunities does my country face in the field of pharmaceutical intermediates?

After nearly 50 years of development of β-lactam antibiotics in China, a complete production system has been formed. At present, almost all β-lactam antibiotics (except the varieties within the patent period) can be produced in my country, and the cost is very low. The output of penicillin ranks first in the world, and a large number of them are exported to the international market; cephalosporin antibiotics are basically self-sufficient. Can also strive for a part of the export.

At present, all the intermediates supporting β-lactam antibiotics can be produced in my country. Except for the semi-synthetic antibiotics, 7-ACA and 7-ADCA, which need to be partly imported, all side chain intermediates can be produced, and a large amount exit.

Taking phenylacetic acid, the main supporting intermediate of β-lactam antibiotics, as an example, there are nearly 30 phenylacetic acid manufacturers in my country, with a total annual production capacity of about 20,000 tons. However, most companies are small in scale, with the largest annual output of 2,000 tons, and other large-scale production of hundreds of tons. In 2003, the total domestic demand for phenylacetic acid was about 14,000 tons, and the consumption structure was as follows: Penicillin G accounted for 85%, other medicines accounted for 4%, spices accounted for 7%, and pesticides and other fields accounted for 4%.

With the development of domestic fragrance, medicine, pesticide and other industries, the demand for phenylacetic acid will further increase. It is estimated that by 2005, my country's pharmaceutical industry will consume about 14,000 tons of phenylacetic acid, the pesticide industry will consume 500 tons, and the perfume industry will consume about 2,000 tons. Coupled with consumption in other areas, it is estimated that the total domestic demand for phenylacetic acid in 2005 will reach 18,000 tons.

In fact, the synthesis of drugs also belongs to the chemical category, but it is more stringent than the requirements of general chemical plants, so pharmaceutical factories need GMP certification, and chemical pharmaceutical intermediates are raw materials for drug synthesis, not drugs, so relatively speaking, the requirements are lower than those of drugs. The manufacturing plant does not require pharmaceutical GMP certification