CAS:14691-88-4 | 4-Amino-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical

Name:4-Amino-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical

Synonyms:4-Amino-TEMPO Free Radical;4-amino-2,2,6,6-tetramethyl-piperidinyloxyl;4-Amino-TEMPO free radical; 4-amino-2,2,6,6-tetramethyl-piperidinyloxyl

CAS:14691-88-4

Purity:>98.0%

Molecular Formula:C₉H₁₉N₂O

Molecular Weight:171.26

Melting Point:37-39ºC

Boiling Point:98ºC / 4mmHg

Flash Point:101.9ºC

Freezing point:36.0 to 42.0 °C

Density:0.962g/cm³

PSA:29.26

LogP:1.95

Appearance:Red to Reddish Yellow to Deep Yellow-Red to Brown to Reddish Brown Solid or Liquid

Stability:Hygroscopic,Heat Sensitive

Water solubility:Soluble

Storage condition:2-8ºC,Store under inert gas

Application:4-Amino-TEMPO free radical(CAS:14691-88-4) is a radical species used as a spin label probe for cellular study. 4-amino-TEMPO is derivitized onto more complex molecular structures, particularly selected to provide target specificity to the probe. Once the 4-amino-TEMPO-containing molecule has reached its target, electron paramagnetic resonance spectroscopy can be used to gather information about the environment in which the radical electron has been approximated. An ATP analog derivitized with 4-Amino-TEMPO is described to bind to actin filaments, generating rotational information of the binding cleft, and providing distinct spectral signatures for different conformations of the filament structure encountered by the bound probe.

Reference: 

 1. Naber, N. and Cooke, R. 1994. Biochemistry. 33: 3855-3861. PMID: 8142388

 2. Vazquez, J., et al. 2007. J. Med. Chem. 50: 2137-2143. PMID: 17394300

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Package:500g/1kg/2kg/5kg/bulk package

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