CAS 848133-35-7 | Trans-4-Dimethylaminocrotonic Acid Hydrochloride
Molecular Formula: C6H12ClNO2
Molecular Weight: 165.62
EINECS: 617-631-8
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg / 25 kg
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Product Introduction
Introduction of CAS 848133-35-7 | trans-4-Dimethylaminocrotonic acid hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate, and it is an important part of the structure of antitumor drugs afatinib and neratinib.
Specification of CAS 848133-35-7 | trans-4-Dimethylaminocrotonic acid hydrochloride
ITEMS | SPECIFICATION |
Melting point | 162 °C |
CAS DataBase Reference | 848133-35-7(CAS DataBase Reference) |
storage temp. | Inert atmosphere,Room Temperature |
Synthesis of CAS 848133-35-7 | trans-4-Dimethylaminocrotonic acid hydrochloride
Conditions
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid methyl ester With water; sodium hydroxide In methanol at 40 - 44℃; for 1.5h;
Stage #2: With hydrogenchloride pH=2;
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