CAS:144481-98-1 Landiolol Hydrochloride
Name:Landiolol hydrochloride
CAS:144481-98-1
Purity:98%
Molecular Formula:C25H40ClN3O8
Molecular Weight:546.05300
Melting Point:122-127ºC
Boiling Point:727.5ºC at 760mmHg
Flash Point:393.8ºC
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Product Introduction
Name:Landiolol hydrochloride<br> | CAS:144481-98-1 |
Purity:98% | Molecular Formula:C25H40ClN3O8 |
Molecular Weight:546.05300 | Melting Point:122-127ºC |
Boiling Point:727.5ºC at 760mmHg | Flash Point:393.8ºC |
PSA:127.82000 | LogP:2.37760 |
Appearance:White crystalline powder | Density:1.201g/cm3 |
Solubility:Methanol (very soluble in);Dimethylformamide (soluble in);Ethanol(slightly sol. in) | Water solubility:Completely soluble |
Vapor Pressure:3.24E-22mmHg at 25°C | Storage condition:Store long-term at 2-8°C |
Application:Landiolol hydrochloride (ONO-1101) is a highly cardioselective, short-acting adrenergic β1-selective antagonist (blocker). Landiolol reduces heart rate by selectively blocking β1 receptors located chiefly in the heart. It is reported that landiolol has 8-fold greater cardioselectivity than esmolol [E1106] in vitro. Landiolol is a short-acting agent since the ester group of landiolol is rapidly hydrolyzed to an inactivate metabolite by esterases in plasma and liver. Landiolol hydrochloride is used for the treatment of tachyarrhythmia and better control of heart rate in surgery. (The product is for research purpose only.)
Reference:
A. Sugiyama, A. Takahara, K. Hashimoto, J. Cardiovasc. Pharmacol. 1999, 34, 70.
G. L. Plosker, Drugs 2013, 73, 959.
Y. Hashimoto, S. Nago, M. Tsunekawa, K. Shibakawa, Y. Miyata, Biol. Pharm. Bull. 2009, 32, 121.
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Package:5g/10g/25g/50g/bulk package
Transportation: by FeDex or by ocean shipping or clients requirement
Delivery Detail: Within 3-5 days after full payment.
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