CAS 1474110-21-8 GSK-2981278

Name:GSK-2981278

Synonyms:GSK2981278;Ror gama modulator 1;Benzenesulfonamide,N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-((tetrahydro-2H-pyran-4-yl)methoxy)-;GSK-2981278;

CAS:1474110-21-8

Purity:≥98%

Molecular Formula:C₂₅H₃₅NO₅S

Molecular Weight:461.61

Melting Point:N/A

Boiling Point:622.6±65.0 °C(Predicted)

PSA:84.45000

LogP:5.47880

Appearance:A crystalline solid

Density:1.180±0.06 g/cm3(Predicted)

Stability:≥ 2 years

Solubility:DMF: 30 mg/ml;DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml;DMSO: 5 mg/ml;Ethanol: 15 mg/ml

Acidity coefficient:14.10±0.10(Predicted)

Storage condition:(-20℃)

InChi:InChI=1S/C25H35NO5S/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)32(28,29)24-9-10-25(22(15-24)17-27)31-18-21-11-13-30-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3

InChi Key:LZLBRISQTJVZNP-UHFFFAOYSA-N

Application:GSK 2981278 (GSK2981278) is a potent, highly selective RORγ/RORγt inhibitor that potently inhibits IL-17A and IL-22 protein secretion in human peripheral T cell with IC50 of 3.2 nM.

Reference:

[1]. Smith SH, et al. Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin. PLoS One. 2016 Feb 12;11(2):e0147979.

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