CAS:74124-79-1 | N,N′-Disuccinimidyl Carbonate

Name:N,N′-Disuccinimidyl carbonate

Synonyms:bis(2,5-dioxopyrrolidin-1-yl) carbonate

CAS:74124-79-1

Purity:≥99%

Molecular Formula:C₉H₈N₂O₇

Molecular Weight:256.17

Melting Point:190° C (lit.)

Boiling Point:383.7° C at 760 mmHg (Predicted)

Density:1.70 g/cm³ (Predicted)

Appearance:White to off-white to tan powder or crystals

Solubility:Soluble in DMSO, hot pyridine, acetonitrile, and most organic solvents. Insoluble in water

refractive index:1.60 (Predicted)

Storage condition:Keep Cold.Store under Nitrogen.

Application:N,N'-Disuccinimidyl carbonate(CAS:74124-79-1) is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate and coupling of ligand to proteins.

Reference: 

Černoch, P.; Černochová, Z.; Kučka, J.; Hrubý, M.; Petrova, S.; Št?pánek, P. Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications. Appl. Radiat. Isot. 2015, 98, 7-12.

Nale, D. B.; Bhanage, B. M. Copper-catalyzed efficient synthesis of a 2-benzimidazolone scaffold from 2-nitroaniline and dimethyl carbonate via a hydrosilylation reaction. Green Chem. 2015, 17 (4), 2480-2486.

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