CAS 139504-50-0 | N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine
Molecular Formula: C35H48ClN3O10S
Molecular Weight: 738.29
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg / 25 kg
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Product Introduction
Introduction
Maytansine DM1 is a tubulin inhibitor that binds at the ends of microtubules and inhibits microtubule dynamics. Maytansine is an antibody-conjugable maytansinoid used to overcome maytansine-related systemic toxicity and enhance tumor-specific delivery.
Specification of CAS 139504-50-0 | N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine
ITEMS | SPECIFICATION |
pka | 9.82 |
Melting point | 190-192℃ (decomposition) |
Density | 1.33 g/cm3 |
Storage temp. | Sealed in dry,2-8°C |
Boiling point | 937.1 °C |
Synthesis of CAS 139504-50-0 | N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine
Conditions
With ethylenediaminetetraacetic acid; diothiothreitol In methanol; phosphate buffer; ethyl acetate for 3h; pH=7.5;
Reference
Widdison, Wayne C.; Wilhelm, Sharon D.; Cavanagh, Emily E.; Whiteman, Kathleen R.; Leece, Barbara A.; Kovtun, Yelena; Goldmacher, Victor S.; (…) Blättler, Walter A.; Chari, Ravi V. J.
[Journal of Medicinal Chemistry, 2006, vol. 49, # 14, p. 4392 - 4408]
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