CAS 961-07-9 | 2'-deoxyguanosine

Name:2'-deoxyguanosine

Synonyms:A-2'-DEOXYGUANOSINE;DEOXYGUANOSINE-2';2'-Deoxyguanosinemonohydrate;guaninedeoxyriboside;2'-DEOXY-D-GUANOSINE;

CAS:961-07-9

Purity:99%

Molecular Formula:C10H13N5O4

Molecular Weight:267.24

Melting Point:300 °C

Boiling Point:725.5ºC at 760mmHg

Flash Point:N/A

Density:2.08g/cm3

Appearance:white crystalline powder

Solubility:NH4OH 1 M: 50 mg/mL, clear to very faintly turbid, yellow to brown

Water solubility:Slightly soluble in water

Stability:Stable under normal temperatures and pressures

Condition to Avoid:Air Sensitive,Hygroscopic

Refractive Index:-42 ° (C=0.2, 1mol/L NaOH)

EINECS:213-505-8

PSA:148.51000

LogP:-1.14060

Storage condition:Keep in dark place,Inert atmosphere,Room temperature

Application

Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

Reference

Kasper Broedbaek et. al. Urinary 8-oxo-7,8-dihydro-2?-deoxyguanosine as a biomarker in type 2 diabetes. Free Radical Biology and Medicine. 2011, 51 (8), 1473-1479.

Aaron M Fleming et. al. Copper/H2O2-mediated oxidation of 2'-deoxyguanosine in the presence of 2-naphthol leads to the formation of two distinct isomeric adducts.. Journal of Organic Chemistry. 2011, 76 (19), 7953-7963.

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