CAS:51067-38-0 | 4-Phenoxyphenylboronic Acid

Name:4-Phenoxyphenylboronic acid

Synonyms:(4-Phenoxyphenyl)boronic Acid; p-Phenoxyphenylboronic Acid; B-(4-Phenoxyphenyl)-boronic Acid

CAS:51067-38-0

Purity:97%

MDL No:MFCD00093312

Molecular Formula:C₁₂H₁₁BO₃

Molecular Weight:214.02

Melting Point:141-145 °C(lit.)

Boiling Point:377.0±44.0 °C(Predicted)

Density:1.23±0.1 g/cm³(Predicted)

Appearance:White to off-white (Solid)

pKa:8.76±0.10(Predicted)

Storage condition:Keep in dark place,Sealed in dry,Room Temperature

InChIKey:KFXUHRXGLWUOJT-UHFFFAOYSA-N

Application: 

1.4-Phenoxyphenylboronic acid can be used as a reactant:

2.In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst.

3.To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions.

4.To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.

References:

Palmer, B., et al.; J. Med. Chem., 53, 282 (2010); Calderwood, D., et al.: Bioorg. Med. Chem. Lett., 12, 1683 (2002)

Packaging & Delivery

Package:5g/10g/25g/50g/bulk package

Transportation: by FeDex or by ocean shipping or clients requirement

Delivery Detail: Within 3-5 days after full payment

Flexible payment terms: support T/T, Paypal , Credit Card

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