3543-74-6 | 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Ethyl Ester

Introduction
5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butyric acid ethyl ester is also called 4-{5-bis-(2-hydroxyethyl)amino]- 1-Methyl-2-benzimidazole}butyric acid methyl ester, an intermediate in the synthesis of bendamustine hydrochloride

Specification of CAS: 3543-74-6 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

Synthesis of CAS: 3543-74-6 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

Stage #1: oxirane; ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate With sodium acetate trihydrate In water; acetic acid at 0 - 25℃; for 23h;

Stage #2: With potassium carbonate In dichloromethane at 20 - 25℃;

Reference:

FRESENIUS KABI ONCOLOGY LIMITED; MISHRA, Bhuwan Bhaskar; KACHHADIA, Nikunj Shambhubhai; TOMAR, Vinod Singh; LAHIRI, Saswata US2014/121383, 2014, A1 Location in patent: Paragraph 0094

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