CAS 2353-33-5 | 5-Aza-2’-deoxy Cytidine

Name:5-Aza-2’-deoxy Cytidine

Synonyms:4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one; 2-Desoxy-5-azacytidine; 2'-Deoxy-5-azacytidine; DAC; Dacogen; Decitabine; NSC 127716; β-Decitabine;

CAS:2353-33-5

Purity:≥99%

Molecular Formula:C₈H₁₂N₄O₄

Molecular Weight:228.21

Melting Point:200 °C (dec.)

Boiling Point:485.8ºC at 760 mmHg

Flash Point:247.6ºC

Density:1.3771g/cm³ (rough estimate)

Appearance:White to Off-white Powder

Stability:Stable. May be light or air sensitive. Incompatible with strong oxidizing agents

Solubility:DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Sonicated)

Acidity coefficient:14.02±0.60(Predicted)

refractive index:1.779

Storage condition:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Application:5-Aza-2′-Deoxycytidine is a Dnmt inhibitor shown to alter gene expression. 5-Aza-2′-Deoxycytidine has been reported to cause phosphorylation inhibition of 2′-deoxycytidine in certain cells and the incorporation of 2′-deoxycytidine into DNA. Experiments have shown that 5-Aza-2′-Deoxycytidine induces changes in the differentiated state of cultured mouse embryo cells and additionally inhibits methylation of newly synthesized DNA. DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention by 5-Aza-2′-Deoxycytidine can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to 5-Aza-2′-Deoxycytidine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin. Furthermore, 5-Aza-2′-Deoxycytidine demonstrates the ability to induce histone hyperacetylation in murine centromeric heterochromatin and also affect intranuclear distribution of histone deacetylase. 5-Aza-2′-Deoxycytidine is also known as Decitabine, 5-Aza-CdR, 5-Aza-dC, and 2′-Deoxy-5-azacytidine.

Reference:

1. Veselý, J., et al., 1977. Incorporation of a potent antileukemic agent, 5-aza-2′-deoxycytidine, into DNA of cells from leukemic mice. Cancer research. 37(10): 3684-9. PMID: 71199

2. Jones, P A., et al., 1980. Cellular differentiation, cytidine analogs and DNA methylation. Cell. 20(1): 85-93. PMID: 6156004

3. Zhu, W G., et al., 2001. DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. Cancer research. 61(4): 1327-33. PMID: 11245429

4. Takebayashi, S., et al., 2001. 5-Aza-2′-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation. Biochemical and biophysical research communications. 288(4): 921-6. PMID: 11688997

Packaging & Delivery

Package:5g/10g/25g/50g/bulk package

Transportation: by FeDex or by ocean shipping or clients requirement

Delivery Detail: Within 3-5 days after full payment.

Flexible payment terms: support T/T, Paypal , Credit Card.

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