CAS:110874-36-7 | 3,4,3-LI(1,2-HOPO)

110874-36-7 3,4,3-LI(1,2-HOPO)

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Abstract

The ability of the spermine-based hydroxypyridone octadentate chelator 3,4,3-LI(1,2-HOPO) to act as tentacles was studied to make Sm{sup III}, Eu{sup III} and Tb emission sensitive{ sup III} In the visible light range (Φ{sub tot} = 0.2-7%) and the near infrared range of Pr{sup III}, Nd{sup III}, Sm{sup III} and Yb{sup III}, at room temperature The decay time varies from 1.78 μs to 805 μs. The special luminescence spectral characteristics of these lanthanide complexes formed with 3,4,3-LI(1,2-HOPO) are used to characterize their respective solution thermodynamic stability and the corresponding La{sup III}, Gd{ sup III}, Dy{sup III}, Ho{sup III}, Er{sup III}, Tm{sup III} and Lu{sup III} complexes. 3,4,3-LI(1, 2-HOPO) and the resulting high complex stability (pM value range from 17.2 of La{sup III} to 23.1 of Yb{sup III}) constitute a necessary but not There are sufficient criteria to consider this octadentate ligand as the best candidate for metal decoration in vivo. Using the radioisotope {sup 152}Eu as a tracer in the rodent model, the ligand's in vivo lanthanide complex stability and decolorization ability were evaluated. This provides a direct comparison with the in vitro thermodynamic results and proves 3 ,4,3-LI(1,2-HOPO) has great potential as a therapeutic metal chelator.

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