CAS 917389-32-3 | LeterMovir
Molecular Formula: C29H28F4N4O4
Molecular Weight: 572.55
EINECS:
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg
- Worldwide Delivery
- Quality Assurance
- 24/7 Customer Service
Product Introduction
Introduction
Letermovir (AIC246, MK-8228) is a novel anti-CMV compound that targets the viral terminal enzyme complex and is also active against viruses that are resistant to DNA polymerase inhibitors.
Specification of CAS 917389-32-3 | LeterMovir
ITEMS | SPECIFICATION |
Boiling point | 706.5 °C |
pka | 4.00 |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
density | 1.37 g/cm3 |
Synthesis of CAS 917389-32-3 | LeterMovir
Conditions:
Stage #1: (S)-methyl 2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetate (2S,3S)-2,3-bis((4-methylbenzoyl)oxy)succinate ethyl acetate With disodium hydrogenphosphate; tert-butyl methyl ether In water for 2h;
Stage #2: With sodium hydroxide In water at 60℃; for 5h; Inert atmosphere;
Reference:
Humphrey, Guy R.; Dalby, Stephen M.; Andreani, Teresa; Xiang, Bangping; Luzung, Michael R.; Song, Zhiguo Jake; Shevlin, Michael; Christensen, Melodie; Belyk, Kevin M.; Tschaen, David M.
[Organic Process Research and Development, 2016, vol. 20, # 6, p. 1097 - 1103]
Hot Tags: cas 917389-32-3 | letermovir, price, quotation, discount, in stock, for sale, Life Science
