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CAS 61260-15-9 | 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic Acid

Molecular Formula: C10H11O5P
Molecular Weight: 242.17
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg / 25 kg
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Specification of CAS 61260-15-9 | 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid

ITEMS	SPECIFICATION
Melting point	97-99℃
density	1.35
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Boiling point	402.0 °C

Synthesis of CAS 61260-15-9 | 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid

Conditions

Stage #1: Dimethyl phosphite; o-carboxybenzaldehyde With sodium methylate In methanol at 0 - 20℃; for 2h; Inert atmosphere;

Stage #2: With methanesulfonic acid In methanol for 0.5h; Inert atmosphere;

Reference

Zmuda, Filip; Malviya, Gaurav; Blair, Adele; Boyd, Marie; Chalmers, Anthony J.; Sutherland, Andrew; Pimlott, Sally L.

[Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8683 - 8693]

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