CAS 501-81-5 | 3-Pyridylacetic Acid

Introduction
3-Pyridineacetic acid is a high homologue of niacin, a breakdown product of nicotine (and other tobacco alkaloids).

Specification of CAS 501-81-5 | 3-Pyridylacetic acid

Synthesis of CAS 501-81-5 | 3-Pyridylacetic acid

Conditions

Stage #1: 3-(bromomethyl)pyridine hydrobromide With sodium hydrogencarbonate In water 

Stage #2: carbon monoxide With palladium hydroxide, 20 wt% on carbon; tetrabutylammomium bromide; water In tetrahydrofuran at 110℃; under 7500.75 Torr; for 4h; Sealed tube; Autoclave;

Reference

Wakuluk-Machado, Anne-Marie; Dewez, Damien F.; Baguia, Hajar; Imbratta, Miguel; Echeverria, Pierre-Georges; Evano, Gwilherm 

[Organic Process Research and Development, 2020, vol. 24, # 5, p. 713 - 723]

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