CAS 480449-70-5 | Edoxaban

Introduction
Edoxaban is a small-molecule oral anticoagulant, a coagulation factor X (FXa) inhibitor. During the coagulation process, activated coagulation factor X (FXa) activates prothrombin (FII) Chemicalbook into thrombin (FIIa), which promotes the formation of fibrin, thereby forming thrombus. target.

Specification of CAS 480449-70-5 | Edoxaban

Synthesis of CAS 480449-70-5 | Edoxaban

To N-(5-chloropiperidin-2-yl)-N'-[(1S,2R,4S)-4-(N,N-dimethylformamido)-2-(amino) at room temperature Methanesulfonic acid (66 ml) was added to a suspension of tert-butoxycarbonyl)cyclohexyl]oxamide (95.1 g) in acetonitrile (1900 ml), and the mixture was stirred at the same temperature for 2 hours. Under ice-cooling, to the reaction solution were added triethylamine (155 ml), 4,5,Chemicalbook 6,7-tetrahydro-5-methyl-thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride ( 52.5g), 1-hydroxybenzotriazole (33.0g), 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (46.8g), stirred at room temperature for 16 hours . Triethylamine and water were added, and after stirring for 1 hour under ice-cooling, the crystals were collected by filtration to obtain 103.2 g of edoxaban, the compound (1).

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