CAS 1346704-33-3 | GSK 343

Introduction
GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, 60-fold selective for EZH1 and >1000-fold selective for other histone methyltransferases.

Specification of CAS 1346704-33-3 | GSK 343

Synthesis of CAS 1346704-33-3 | GSK 343

Conditions

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium hydrogencarbonate In 1,4-dioxane; water at 110℃; for 0.333333h; Inert atmosphere; Sealed tube; Microwave irradiation;

Reference

Verma, Sharad K.; Tian, Xinrong; Lafrance, Louis V.; Duquenne, Céline; Suarez, Dominic P.; Newlander, Kenneth A.; Romeril, Stuart P.; (…) Creasy, Caretha L.; Miller, William H.

[ACS Medicinal Chemistry Letters, 2012, vol. 3, # 12, p. 1091 - 1096]

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