CAS:816-94-4 | 1,2-Distearoyl-sn-glycero-3-phosphocholine

Name:1,2-Distearoyl-sn-glycero-3-phosphocholine

Synonyms:1,2-Dioctadecanoyl-sn-glycero-3-phosphocholine;(R)-2,3-Bis(stearoyloxy)propyl [2-(Trimethylammonio)ethyl] Phosphate;DSPC

CAS:816-94-4

Purity:99%

Molecular Formula:C₄₄H₈₈NO₈P

Molecular Weight:790.16 

Melting Point:236°C(lit.)

Boiling Point:N/A

Appearance:White powder

Sensitivity:Heat Sensitive

Stability:Stable. Incompatible with strong oxidizing agents.

Solubility:Soluble in water;Ethanol: 25 mg/ml

Storage condition:Store at -20° C

InChi:InChI=1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

InChi Key:NRJAVPSFFCBXDT-HUESYALOSA-N

Application:1,2-Distearoyl-sn-glycero-3-phosphocholine(CAS:816-94-4) is a non-pyrogenic phospholipid that has been shown to form well-defined liposomes that are capable of being loaded with a molecule of choice. This loading and vessicle formation is reportedly accomplished simply by a single hydration step. Research has shown that this encapsulation technique has been shown to increase the uptake for 125I-labelled polyvinylpyrrolidone by four times in an intestinal sac preparation from adult rats. More recently, compounds such as 5-fluorouracil (sc-207031), cyclosporin A (sc-3503) and celecoxib (sc-217869) have been used in this lipid encapsulation technique.

Reference: 

1. Rowland, R.N., et al. 1981. Biochim. Biophys. Acta. 673: 217-223. PMID: 7213821

2. Malaekeh-Nikouei, B., et al. 2009. PDA J Pharm Sci Technol. 63: 139-148. PMID: 19634352

3. Deniz, A., et al. 2010. Biosci. Rep. 30: 365-373. PMID: 19900165

4. Thomas, A.M., et al. 2010. J Control Release. [Epub ahead of print]. PMID: 21094191

5. Ali, M.H., et al. 2010. J. Pharm. Pharmacol. 62: 1646-1655. PMID: 21039548

Packaging & Delivery

Package:50g/100g/250g/500g/bulk package

Transportation: by FeDex or by ocean shipping or clients requirement

Delivery Detail: Within 3-5 days after full payment

Flexible payment terms: support T/T, Paypal , Credit Card

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